W. S. CAIN, M. D., was born January 26, 1827, in Crittenden County, and is a son of Charles and Ellen (Stewart) Cain. Subject's paternal grandfather was William Cain. He was born in South Carolina, and shortly after the Revolutionary war moved to Georgia, where he lived until 1806, when he immigrated to Kentucky, and settled in what is now Crittenden County, near where subject still lives. He died in 1842 or 1843. William Stewart, subject's maternal grandfather, was a native of South Carolina, also. He moved to Kentucky in 1806 and settled near Piny Creek, in Crittenden County; he afterward moved to Illinois, in which State his death occurred in 1856. He was a soldier in the Revolution and received a severe wound at the battle of Camden. Charles Cain was born in Georgia in 1796, and was but ten years old when his parents moved to Kentucky. He was a resident of Crittenden County for sixty-five years, dying here in 1871. Mrs. Cain was born in South Carolina, and died in Crittenden County in 1872, at the age of seventy-two years. Subject is the second of a family of seven children born to Charles and Ellen Cain. At the age of twenty-two years he engaged in teaching school, which he followed for two years. In 1851 he commenced the study of medicine with Dr. Gillam, of Marion, in whose office he remained two years, and at the end of that time commenced the practice of his profession at Bell's Mines, where he remained until 1855. In the latter year he came to Marion and effected a co-partnership with Dr. J. A. Hodge, which was continued one year. In 1857 Dr. Cain entered the St. Louis Medical College, from which he graduated in March of the following year. After leaving college he returned to Marion, where he practiced his profession until 1877, at which time he moved to Illinois, locating at Cave-in-Rock, where he remained two years. From Cave-in-Rock he came to Weston, this county, and in 1882 moved to his present location five miles northeast of Marion, where he has since practiced his profession. Dr. Cain was married June 24, 1859, to Mrs. Mary A. Bence, daughter of Marcus Twitchell, of Ohio. Mrs. Cain died July 29, 1870, at the age of forty-two years. The Doctor next married, December 31, 1870, Mrs. Susan A. Peck, daughter of John M. and Mary E. (Jackson) Carter, of Henderson County, Ky. Three children have been born to Dr. and Mrs. Cain: Maggie D., Dixie and Kittie S. By previous marriage Mrs. Cain had one child, who has since been adopted by the Doctor; its name is William Walter Cain.
Source: J. H. Battle, W. H. Perrin, & G. C. Kniffin. Kentucky. A History of the State. Louisville, KY, Chicago, IL: Battey, 1885. Page 720.